The Murfree-Smith Law Office, built during the first decade of the nineteenth century, was originally designed to serve two functions. The eastern and larger portion of the building, along with the basement, was to serve as a store, possibly for use by the Gordon and Murfree mercantile partnership. The western part was intended to serve as a law office for William Hardy Murfree, grandson of William Murfree, founder of the town.
Changing ownership many times, the building was later used as a law office by William Nathan Harrell Smith, the first native son to become Chief Justice of the Supreme Court.
Tradition has it that the building has served variously as a theatre, jail, school, and post office. Noteworthy features of this structure are its Flemish bond walls and original dentil work. Some original interior woodwork remains.
In the 1970s the building was purchased and restored by the Murfreesboro Historical Association.
It currently houses a medical display which features medical instruments similar to those which Dr. Walter Reed may have used.